Webinar: Diet, Genes and Your Health: Unlock Your Genetic Potential with the Science of Epigenetics

now I’d like to introduce our featured presenter today dr. Lou Chia or Annika Lucia’s a professor at the Stanford Prevention Research Center and primary teach of the epigenomics and microbiome X module of the Stanford genomics certificate at the Stanford center for professional increase Lucia’s currently heading the epigenetic analysis of the Stanford diet fit study by Professor Christopher Gardner the largest randomized clinical visitation ever undertaken to compare low carb vs. low fat diets for the design of personalized weight loss strategies the focus of her research is investigating how diet feigns the epigenome and whether we can use epigenetic biomarkers to design personalized weight loss hopes Lucia too dishes as an advisor for corporations active in the personal genomics and precision health battlefield Lucia received her PhD from the University of Vienna and has study ordeal from the University of Oxford University of Southern California and University frederico ii of naples she has published research papers in top-ranked peer-reviewed journals such as cell genes and occurrence and the EMBA journal and with that let’s turn it over to Lucia so thank you very much for having me here it’s a pleasure to talk today about unlocking your genetic capability consuming the social sciences of epigenetics and this is an why so my Y my goal is using science to live healthier happier life and helping people achieving this you can follow us at IP wellness and find more information at dr.Annika com I do these through my research and teaching if my study could be a painting it is likely to be this draw now and not because the author Giuseppe Archibald OH was Italian as I am the reason is that Josephus seemed to know that food chassis our biology and it done likewise through through two handles that are the cornerstone of my investigate here at Stanford nutria genetics and nutrigenomics neutral genetics describes how genes can affect our response to diet whereas nutrigenomics describes how diet can affect our gene show so this is like a give-and-take a sort of conversation and it’s a and this is my main research interest now at Stanford but I also learn various courses at Stanford in person and online and yes you can get notified about new direction launches at dr. Anka calm my experiment is the driving engine of my teaching but my learn on the other side is the fuel of my study I get a lot of motivation from teaching and many students “ve been told” that they come out of my directions empowered to use science to improve their health and I to be expected that today I can give you a taste of that and you can take home some senses actionable information to improve your state so today we will learn about what is epigenetic and how it is different from genetics how diet are affecting our epigenetics and health and now epigenetics can help us make proprietors carry on our state so understanding the difference between epigenetics and genetics is especially important now that there are several firms consuming genetic testing to predict everything about us what we should eat where and even what kind of music should we listen to but so all these companies work in the cavity of precision health which is a brand-new progressive health care approach aiming at predicting thwarting and medicine illnes precisely by consuming biological markers that are unique for so they are pretty weak for people personalized characteristics and these biomarkers are genomics epigenomics as exposomics so the part give of environmental causes we are exposed to metabolomics the metabolites in our torso proteomics all the proteins in our cells and tissues and microbiome the universe of microbes within the americans and on us but most of the companies in the accuracy health space are now working only genomics but we know that the other omics scientists they’re announced life omics are actually responsive to what we do to our environment our lifestyle and therefore are of particular interest in the field of preventative medication and life-style prescription and they can also enhance the predictive superpower of genomics markers were measured alone so why do we need to integrate genetic testing with life omics markers for precise health prophecies let’s have a genetic refresher – in order to answer this question our DNA is made of four four building block for nucleotide nucleotides apgc that add the information for structure the cycle of the amino battery-acids in the proteins that build up our cells and tissues and a multi-billion dollar project direct from the 90 s until 2003 the human genome project aimed at sequencing the entire sequence of the human genome and genome and there was a lot of hope behind this project and I was one of of the people very excited about this project actually I started my university studies in 2000 and this was one reason for me to to decide to inside to pursue studies in molecular biology and genomics and scientists were literally potting on how many genes would turn up when the human genome will be finally met and but the human genome as you may know produce some outraging surprises the first shocking surprise is the fact that we humen have actually the same moral the same number of genes as a simple model structures such as mice fruit flies and worms and 50 terms fewer than an onion the second shocking surprise was that genes account for only 2% of our DNA and if that weren’t enough to hurt our genetic egos there is a third shocking surprise who really your guinea is 99.9 similar to any other person’s DNA so technically speaking our DNA can explain only 0.1 percent of what perform us unique and therefore is perhaps not surprising that too my genetic report was not very accurate in prophesying my whisker nature so according to my JD report I’m 72% likely to have straight hair and for the same reason we were not surprised when we received the genomic reactions for our study the nutrition fit study this is a study by Professor Christopher Gardner with the 609 the overweight and obese men and women that are randomized to either low-grade carb or low fat diet that they be used for one year we are measuring genomics epigenomics microbiome Ickx proteomic mass markers for research studies and we publish the research results for for the genetic part and we actually could not replicate some genetic associations that had been published previously affiliating a three genes in the mucus and fat metabolism with the prediction of diet response I’d look up or low fat and that’s why we are now focusing on epigenetics and we are measuring the DNA methylation looking for epigenetic biomarkers of diet response so what is epigenetics you may remember the 2008 mask of the Time magazine stating that the brand-new science of epigenetics reveals how the choices you stir can change your genes and those of your kids so epigenetics to to understand epigenetics let’s just describe the meaning of the world that comes from the Greek language where a key implies above on the top so if your DNA is your genome then your epigenome is actually a aim of molecular markers chemical groups that are on the top of your DNA and can swap genes on and off just like a dimmer substitution can modulate glowings up and down in room and this process of turning genes on and off can explain why we have different types of cells in our body liver cells neurons fatten cells all towering more than 200 each type of cells or the expedition shares the same DNA the same information so how is this possible well think of your DNA your genome as Hardware then the epigenome is software that can turn genes on and off specifically in different cadres so here each cells each cell will turn off a Civic set of genes and turn on only those genes that are required for its name and function to understand the application we need to understand two fundamental dimensions of the epigenome epigenetic flexibility and remember so unlike genetic string our genome is flexible and dynamically responds to lifestyle causes and this is both this Athens once very early in man so when the egg and sperm fused together actually they kill all almost all the genetic marks rendering rise to embryonic stem cells these stem cells can become any type of cell because they don’t have epigenetic markers to advise the cell about which genes to turn on and off but when during the embroidery fetal development these cell do acquire epigenetic tags then they do start distinguish in the different types of cadres that even up our figure and as you can imagine embryonic and fetal blooming are there are time windows that are particularly sensitive to lifestyle factors and that’s this is a reason why pregnant women should be especially careful of their lifestyle because this can have massive impact on the epigenome of the developing fetus there are many lifestyle ingredients feigning epigenome diet pollutants stress remedies compounds additives and the acces these lifestyle points can impact our P genome and gene formulation is by sending signals to enzymes proteins that either privilege kill or speak epigenetic modifications on our genes does affect altering the gene construction therefore you can think of the epigenome as a adjust of sticky notations is available on your genes that can store an epigenetic molecular memory is called epigenetic recognition of your lifestyle shows the fragile balance between opennes and molecular stability is what utters it possible for our cells to collect an epigenetic storage epigenetic scores are flexibly modified by lifestyle influences but they’re stable through cell division and can be therefore elapsed to the daughter cadres and this prepares intermittent recall possible now the nodes the markers that are written before our birth tend to be written in pen so they tend to be permanent whereas the notes that are taken after our birth are potentially reversible as if written with a pencil and both write and pencil markings can affect our state and home post for infections so while genetic factors can help to our swaps through a process of hardwiring epigenetic markers do so by a process of soft cable that is dynamically influenced by our environment lifestyle and that’s why for example identical twins that have exactly the same DNA can with hour not only examine different but too develop different clergymen position to disease now there have been a thousand studies on the impact of diet of on our epigenetics and actually epigenetics provides an opportunity for us to look at diet from a brand-new attitude nutrient is not on the calories its information is the most important signal powerful signals to our genes and it can actually modulate various of those enzymes that can bright erase and grid epigenetic modifications one of the most famous studies in animal around diet and epigenome is a study coming from a beehive so queen bees are much larger than other bees in a beehive that are called proletarian bees they also live longer and they are first time they can lay eggs whereas worker bees cannot what i am surprising is that queen bees and craftsman bees are genetically same and what is even more surprising is that the only difference is that only queen bees are fed imperial jelly a protein-rich substance that is actually secreted by laborer bees and these tells a great deal about fairness in mood and that can actually turn on specific genes that spawn the queen become a queen but before you run to your local place and buy sovereign jelly I have to tell you that this doesn’t seem to work for humen we do have nutrients that we know are acting through an epigenetic mechanism and we are discovering every day new nutrients in this category I call these nutrients playing nutrients these are our royal jelly the nourish our epigenome and open our full potential here is a table with some of these at nutrients so the one here on the left in orange are nutrients that can actually afford the building blocks for compiling the substitutions epigenetic swaps this include methionine folate vitamin b1 2 b6 choline detain and the nutrients on the right this one in violet they can actually modulate the activity of those the authors and racers and books and so affect our epigenome these include numerous polyphenols such as for example those from lettuce tea resveratrol from red wine some flavonoids in soy genestein sulforaphane a very famous IP nutrient found in all cruciferous veggies and broccoli elegance charge a very interesting nutrient that is actually produced in the gut when dietary fiber is fermented and so it’s so so heavily dependent on our microbiome and then died a little sulphide or that’s from garlic so all these studies are showing that we are what we eat but they’re even studies that suggest that we may actually be given our what our parents and grandparents chew one of these studies is again an animal study and these two mice there is pythons as you can see one is yellow and fatty and the other is brown and lean and the game astonishingly this micelle genetically same they both have a gene announced called the agouti practicable yellowed allele or ABY that genetically platforms these mouse to become fat developed yellow-bellied coat and develop late later in life diabetes but the ADI gene is turned on exclusively in the yellow fat mouse why actually this is because of the nutrition of their the mother of this mouse so for the yellowed Mouse the matter of the yellow Mouse had a diet was poor in epping nutrients and for these reasons her daughter couldn’t construct the building the the the building blocks of the epigenome and switch off the ady a lean during embryonic exploitation whereas the mother of the Lingga brown mouse was reacting well and ingesting all these a key nutrients was fed the nutrition was complemented to those used nutrients and as a result her daughter could turn off the ady gene but what about humans is there some evidence that we could also be what our parents and grandparents ate well there is evidence not from an experiment but from a historic tragedy this was a Dutch hunger winter during World War two there was a food embargo in Holland and as a result more than 20,000 parties died as you can imagine the the mothers the the the babies born during the famine were underweight and had a lot of health issues and this is not surprising but what is surprising is that when these children became adults we are really developed well they were more more prone to develop diabetes diabetes and become obese and what is even more surprising is that the children of the fanning babies had previously been a higher risk of becoming obese and developing metabolic sicknes although they were never exposed in to the famine so recently scientists found out that actually in actually the the famine children had persistent epigenetic varies especially in some genes adjusting metabolism glucose metabolism and solid metabolism which suggests that there was there were some epigenetic distinguishes written in pen during the famine that persevered later in life and had long-term consequences of on the metabolic state of these parties and but is not simply the diet of the mother is important too the diet of leaders and these a recent study showing that actually the epigenetic commemorates in the parent cadres of obese beings are dramatically different from those detecting lean people and they are found in genes that regulate brain function and craving which establishes smell from a mechanistically point of view to explain the problem with the obesity and metabolic disease and even more surprising when these people these beings go through but attic surgery and lose weight also these epigenetic markers switch from the obese kind to the lean type so this recommends actually yo bgt affiliated epigenetic markers in sperm cells may actually be written with a pencil and this wreaks us to the most important topic of this chide we want to use at genetics to live a healthier happier life and empower us to take ownership on our genes and our state and to do so we should move from a paradigm of fright of canker to one of opportunity for health just think about your genes as the starting line in your health wander the good and bad predilections you were born with and the lifestyle omics are your path to state the really the biology that you improve every day by making your lifestyle picks so high-pitched hope that you can embrace now-why lifestyle omics significance and I will show you one one last-place precedent from recent studies in which investigates linked a polygenic compose able to predict the risk of coronary heart after a calcification for a cardiac infarction in people and then they looked at how these people could actually predict disease in three different categories of people some of them at a favorable life with the utilization and healthy food some of them and intermediate lifestyle here in gray and then some an unfavorable life in in red now as you can see actually even if you have a high genetic hazard now on the on the on the right in blood-red actually you have a positive life in off-color this can cancel out the your your genetic predilection you see it’s the blue the blue bars are the same height in the in the intermediate and high-pitched lists so it means that mostly if you have a positive lifestyle here in blue certainly doesn’t matter if you are you know a high genetic gamble and this is what I actually hope to have shown to you in this presentation so I hope that now you can embrace that we are unique in many ways and two of these ways are our genes the book your mothers wrote for you and the other more interesting book is your lifestyle the book you write every day and can impact your lifestyle omics and remember that diet is one of the most powerful epigenetic pencils you have in your hands and with this I would like to thank you for your attention and yes satisfy follow us at epi Wellness thank you very much Lucia for this very important event ation and now we will move on to answering your questions the first question here is what are some recommended learnings or resources to learn more about the topic of epigenetics I depends on what height of so if you miss a very deep dive I always recommend the books on the book on epigenetics I recollect now is the third edition by David Ellis and Thomas genuine that is a wonderful book and otherwise I do like reading articles that I know that is a jungle for for most people I think that’s also some some websites like what is epigenetics that can be also very helpful so our next question is how far does the epigenetic flexibility arrive involving diet and does one snack alter as much as lifelong dietary habits oh I desire I could greeting a huntress crusade answer this question with a precise answer we don’t know we because we don’t have studies that have likened one single dinner versus a long-term diet revelation but we do know that actually epigenetic some epigenetic assessments can change very rapidly such as those that are responsible for example to prompt brand-new responses we need to switch on and off those genes very very quickly and so certainly we can we can predict it’s very likely that even after one meal your there would be some epigenetic reforms – the big question is whether these actually affair for your long-term health it seems that for example if you just wanted to make some metabolic issues or obesity those alters require longer exposure for example longer diet intervention even the rate of a change depends on how how strong the showing has been and how long for example in case of obesity how long disposer to an obesogenic diet has been and how long have been overweight the reason i potus’s according to which actually people may have harder era losing force because of some epigenetic stiffness so the opposition of some of those pencil distinguishes to actually be rubbed so to come back to your question is really the acceleration of reversion is very really an individual issue so the next question somewhat associated which is are happen happy nutrients more important during special parts of a person’s life for example pregnancy or childhood yes yes as I as I mentioned under my lecturing pregnancy in childhood are especially important because the the fetus during variant change our epigenome is just have been put in place I describe it as an naked at dinner or approximately naked so of course the the older lives environmental signals in that time window are are going to have a bigger impact and are going to be potentially written in pen I too want to mention it actually it’s a good thing think that we have markers that are written in pen because those markers are essential to establish cadre identity otherwise we would have our mane turning into a nose or something like that so it’s good that those markers that are established during burning progress tend to be written in pen but the downside is that some of the markers that are established for example in response to a berthed or adverse licensure might as well then end up written in pen okay so the next question is actually involving that which is is there a behavior to turn off the genes that can impact health negatively for example the dearth genes yeah again there is evidence of epigenetic change of some disease associated epigenetic markers I’ve sure present you the speciman of the obesity affiliated markers in the seman of of husband but actually we ascertained smokers smokers smoking associated epigenetic markers are exceedingly like is a good one studied and actually investigates have shown that those markers can be turned after 16 times so after ceasing with smoking so there is evidence again the rate of overrule depends on the show and the type of exposure and is someone on the person is it possible to discriminate if stop or exit signal through CRISPR caste 9 or similar editing gene organisation yeah so this is more like a genetic question right so “youre here” your suggestion is to manipulate actually the DNA sequence we cannot do that now I make there is ongoing research in animal 2 to achieve that but I’m a follower of you know lifestyle medicine intervention so rather than changing the DNA changing the space it works the next question is I educate health and PETA high school students we’re starting nutrition soon any feelings or clues to change their good diet for 14 to 16 Wow so this is a awesome more like more better genomic question what diet question so the issues to what do we know about what what is the most impactful involvement we we can do to to improve our state and perhaps our epigenetics well for sure there is a consensus on the reduction reduction of refined grains and contributed carbohydrate sugars there are epigenetic field some trips be said that sugar can actually trigger epigenetic modifications that attached metabolic cancer to other maladies “thats associated” to a B city including cancer so what we know from dietary recommendation is also a more profound so indication in our death by all genetic genetics reduction of refined particles and sugars is for sure important than a diet that is rich in fiber to promote the microbiome there is also now new research indicating actually a crosstalk between our microbiome and our epigenetics so those two are our two areas of very important now and then of course the the third is excellence of food good quality of obesities and and carbohydrates so carbon is primarily from vegetables and and details likewise from natural flabs not hydrogenated industrial fattens okay so you mentioned the epigenomic persona of the leader affects brain function and appetite button genes but what about the mother and to what extension can an unhealthy baby improve make any potential damage you might have superimposed on her unborn fetus yeah so regarding the effects so the the the genes that presented differential epigenetic modifications and expression in the Fanning newborn so for the one that were modified as a consequence of the model shows those genes been particularly metabolic genes so genes involved in the glucose and solid metabolism and as I mentioned studies and research about how to switch those assessments is ongoing there is there is hope actually genetics is the science of hope whereas epigenetics during the feminism may persuasion beings to think okay I’m stuck with my genetics there’s nothing I can do epigenetics sacrifice us a tool to actually take action on our health and be enhanced our state there is research as I mentioned showing that many of those traces can be overturned even even those in the fetus four are not all written in pen not all the notations written during fetu Val are written in pen so I think it’s really important to act as soon as possible in case of children that have been exposed to adverse environmental exposures during during teenage pregnancies it’s important to to act as soon as possible because too childhood is a very sensitive time window for the epigenome and by doing so and focusing on all the environmental points that we know can benefit epigenome diet is one of them but likewise these emotional state and environmental health exposure to chemicals I’m sure you can optimize you can minimize the effects of a bad show during the pregnancy and maximize the likelihood of a way driving life-time for your children okay so there was a couple of additional questions now and we have a little bit more time and so someone had asked they had their entire genome mapped what should they be asking when they see the results wow this is a big question so it’s actually very exciting and now more corporations are are offering the mapping of the entire genome as you may know there is a difference between a mapping the part genome or genotyping through a service like for example 20 trainee or other genetic tests companies but now there is also the question how to use that message this is a big question here Jenny testing can be a double-edged sword so on one side can actually empower beings to taking any decision all of their health you can say okay I have this press position to absorb less folate from my diet so I will devour more of that but on the other side this can also trigger some nocebo gist like for example people can can feel that yeah they have bad genes and that’s not they can do there is actually an interesting study published by Stanford researchers a couple of months ago showing that parties that received forgery genetic composes is forecast that they were going to perform poorly on a treadmill then actually when they did and they did the pair the treadmill test and they did perform poorly but those were fake genetic orchestrates so my point here is when you receive this genetic info there are the there are some genes that you can look at there are a few genes that are really backed up by by convincing suggestion and these are especially genes in the regulating our answer to micronutrients like folate and likewise some other vitamins vitamin B and likewise the omega-3 so there’s some people for example that have some genetic polymorphisms that perform us less efficient at proselytizing bush Omega threes to biologically active eth DHA so that there is there is a evidence the dark or Jerry polymorphisms are backed by evidence but you should always be aware that those our complex peculiarities all our characteristics even our response to food are actually cheapened by hundred thousand genes and that’s why it’s very difficult to predict them precisely only by testing one example is height altitude is highly genic genetic so isn’t easy it’s an extra it can be explained like from eighty to ninety percentage by genes but because it’s affected by more than 100 thousand genes there is actually now no genetic evaluation that is going to predict able to believe height so my pitch here is yes disappear look at some there are areas that you can look at like micronutrients omega-3 react so methylation pathways cardio metabolic state but delight be aware that those are only prognosis with the with the low-spirited predictive power because complex peculiarities are affected a thousand genes and hopefully one day when we will be able to integrate those general predictions with other multi-omics markers that I testified you then we’ll be able to announce the creativity of those markers and and be more confident about their signify for our help thank you all right well unfortunately we’re getting close to the hour so we’ll have to wrap up the Q& A session thank you very much dr.Orr Annika for sharing your acquaintance with our participants today for those of you who have indicated an interest in the course our unit will be reaching out with more information and you can always visit us at genetic authorization stanford.edu as a final reminder sound recordings of this webinar will be emailed to you within a week thank you all for meeting us today and have a great rest of your week.

pexels photo 2383009

Loop whole how to drop 2 1/2 in 24 hours

You May Also Like